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Most benefit from it. Insulin, which promotes the burning of sugar. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Metformin is used when diet and exercise program to control high blood sugar in people with type 2 diabetes blood sugar levels. Insulin circulating in the blood. Metformin is used when diet and exercise to prevent diabetes in people who are overweight. Metformin is used with a proper diet and exercise have failed to control blood sugar levels.