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Serious interactions of Cephalexin with other drugs are uncommon. Cephalexin belongs to a class of antibiotics called cephalosporins. Cephalexin is a broad-spectrum antibiotic used to treat a wide variety of bacterial infections. Keflex is a cephalosporin antibiotic used to treat a wide variety of bacterial infections. Keflex can be used as first-line therapy for MRSA infections and is the most prescribed oral cephalosporin medicine. Keflex is a semi-synthetic cephalosporin antibiotic for oral administration.