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Depression, Celexa extends the length of time serotonin remains active in the brain. Celexa insomnia may be a side effect from this drug prolonging serotonin's action within the brain. Celexa is a selective serotonin reuptake inhibitors. As Celexa is designed to prolong this neurotransmitter's activity to effectively treat depression it could be implicated in Celexa insomnia. Citalopram is an antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. The levels of serotonin in the brain called serotonin. Celexa appears to be safe to use on a long-term basis and may cause less withdrawal when use is stopped. It is recommended that Celexa be administered as a single daily dose, usually in the morning.