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Athletes and bodybuilders who use anabolic steroids and other performance enhancing drugs, frequently use Nolvadex in order to block estrogen that result as a side effect from using drugs. Nolvadex is useful during a diet since it helps in the burning of fat. Tamoxifen citrate works by competitively binding to target estrogen sites like those at the breast. Nolvadex is certainly the most popular anti-estrogen among steroid users by far. This receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved. Tamoxifen use in women has been shown to cause miscarriages, birth defects, death of the fetus, and vaginal bleeding. In women Nolvadex is used to mainly prevent gynecomastia. A high risk of developing breast cancer.